1896: The Island of Doctor Moreau
Author: H. G. Wells
While not Wells’ best writing and not my favorite of his works (that would be ‘The Invisible Man’), this sci-fi novel does exemplify his uncanny knack for subject matter that seems to predict future (though with a much longer lead time than Michael Crichton). The British Union for the Abolition of Vivisection was created in 1898, two years after the publication of this novel, in which experimentation on animals is highly featured.